![]() NASHP’s Hospital Cost Calculator (HCC) is designed for hospital reporting only, using CMS 2552-10 format. The facility must complete and file a cost report on a yearly basis, due five months after its fiscal year end. MCRs are required filings for Medicare-reimbursable facilities, such as hospitals, skilled nursing facilities, home health agencies, home offices, hospices, rural health clinics, federally qualified health centers, and comprehensive outpatient rehabilitation facilities. A subscription fee is required, and fees vary depending on access levels requested (e.g., a single hospital report or all hospital reports). Private businesses have also developed databases to house the HCRIS data, format MCRs, and provide analytics.Downloading data in SAS dataset format is available from CMS. CMS maintains MCR data in the Healthcare Provider Cost Reporting Information System (HCRIS), which is the only government national database available for all types of hospitals (nonprofit, for-profit, and government).For more information on this process, visit the CMS FOIA page. Individual hospital MCRs may be requested from Medicare administrative contractors via the Freedom of Information Act (FOIA).Each state is different, so an inquiry with the specific agency that oversees hospital reporting will confirm if the MCR is filed with the state and if public access to the report is permitted. States may require hospitals to submit their MCRs to a state agency.To gain access to a hospital’s MCR, there are four possible options: In addition, it includes Medicaid cost, charges, and supplemental payments as reported by the hospital. The MCR includes hospital utilization data, costs and charges by cost centers and payers, related party and home office costs, and hospital reimbursements. Chronic Disease Prevention and Managementĭownload NASHP’s Hospital Cost Calculator (Excel spreadsheet).Īll Medicare-certified hospitals are required to file an annual MCR, using the Centers for Medicare & Medicaid (CMS) 2552-10 format, comprised of a series of worksheets and schedules that describe a hospital’s characteristics, financial information, costs, and charges.Primary Care/Patient-Centered/Health Home.Integrated for Pregnant/Parenting Women.Healthy Child Development State Resource Center.Physical and Behavioral Health Integration. ![]() The RAISE Family Caregiver Resource and Dissemination Center.Children and Youth with Special Health Care Needs.
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Did Loan’s action violate the Geneva Conventions for treatment of prisoners of war? Photographer Eddie Adams recalled that on his last visit to the pizza parlor, he had seen written on a toilet wall, “We know who you are, fucker”. Nguyen Ngọc Loan died of cancer on 14 July 1998, aged 67, in Burke, Virginia. In 1991, he was forced into retirement when he was recognized and his identity publicly disclosed. suburb of Burke, Virginia at Rolling Valley Mall called “Les Trois Continents”. He opened a pizza restaurant in the Washington, D.C. After an Australian hospital refused to treat him, he was transferred to the United States, where he was met with a massive (though unsuccessful) campaign to deport him. A few months after the execution picture was taken, Loan was seriously wounded by machine-gun fire that led to the amputation of his leg.įollowing the war, he was reviled wherever he went. Sadly, the photograph’s legacy would haunt Loan for the rest of his life. What happened to General Nguyen Ngoc Loan after the war? He told me if I hadn’t taken the picture, someone else would have, but I’ve felt bad for him and his family for a long time… I sent flowers when I heard that he had died and wrote, “I’m sorry. What the photograph didn’t say was, ‘What would you do if you were the general at that time and place on that hot day, and you caught the so-called bad guy after he blew away one, two, or three American people?’… ![]() People believe them but photographs do lie, even without manipulation. Still, photographs are the most powerful weapons in the world. The general killed the Viet Cong I killed the general with my camera. Two people died in that photograph: the recipient of the bullet and General Nguyen Ngoc Loan. He felt so bad for Loan that he apologized for having taken the photo at all, admitting, “The general killed the Vietcong I killed the general with my camera”. Adams wrote in Time in 1998: Photographer said he had a lot of sympathy for the shooter and wished he had never published the picture. 38 revolver, executed Lém with a single shot in the head. Lém was brought to Loan who questioned him briefly then using his personal. Photographer Adams confirmed the South Vietnamese account, although he was only present for the execution. Corroborating this, Lém was captured at the site of a mass grave that included the bodies of at least seven police family members. South Vietnamese sources said that Lém commanded a Vietcong death squad, which on that day had targeted South Vietnamese National Police officers, or in their stead, the police officers’ families. Vietcong officer Nguyen Van Lem under arrest. ![]() Regardless, it instantly became an icon of the war’s savagery and made the official pulling the trigger – General Nguyen Ngoc Loan – its iconic villain. ![]() What Adams’ photograph doesn’t reveal is that the man being shot (named Nguyen Van Lem) was the captain of a Vietcong “revenge squad” that had executed dozens of unarmed civilians earlier the same day. A fitting quote for Adams, because his 1968 photograph of an officer shooting a handcuffed prisoner in the head at point-blank range not only earned him a Pulitzer Prize in 1969 but also went a long way toward souring Americans’ attitudes about the Vietnam War.įor all the image’s political impact, though, the situation wasn’t as black-and-white as it’s rendered. “Still photographs are the most powerful weapon in the world”, AP photojournalist Eddie Adams once wrote. The gif from the execution (graphic images!). A closer look at the photo actually reveals the bullet exiting his skull. Taken a split second after the trigger was pulled, Lem’s final expression is one of pain as the bullet rips through his head. 1, 1968.Īfter Nguyen Ngoc Loan raised his sidearm and shot Vietcong operative Nguyen Van Lem in the head he walked over to the reporters and told them that: “These guys kill a lot of our people, and I think Buddha will forgive me”.Ĭaptured on NBC TV cameras and by AP photographer Eddie Adams, the picture and film footage flashed around the world and quickly became a symbol of the Vietnam War’s brutality.Įddie Adams’ picture was especially striking, as the moment frozen is one almost at the instant of death. Nguyen Ngoc Loan, chief of the national police, shoots Vietcong officer Nguyen Van Lem, also known as Bay Lop, on a Saigon street on Feb. ![]() Ready for something a little longer? 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This seemingly usual trip will lead to a chain of events. ![]() You will see the story of Kate, a brilliant US lawyer. The game is often characterized as a playable movie.Īnd this is a very good way to characterize Syberia. Here is another great game that will surprise you with its graphics and stunning plot. You can get the app on the App Store and Google Play. You’ll have to pay 6.99$ to download the application. However, the developers try to fix bugs so they are highly likely to solve such a problem. When they appear you need to close the app and open it again. Many people criticize the game because of its bugs. Some scenes display graphic content, such as blood and murders. Please note this game isn’t for children. When you feel you can’t find the answer, go back to the previous level and review them to get some information.
The game has been up for about 9 years since its release in 2010 and still has players around the globe and has been played over 2 million times in the armorgames site alone, which is really impressive for such a simple game run on flash player. The immersive suspenseful music is a bonus that adds to the fun of the gameplay. Strategising and balancing your resources is the main challenge of the game and it’s really fun all in all from the highly realistic modern games we play in current times. The game also provides players the option to create their own maps and upload them, using the in-game map creator. You can create a free account and use it to save your data in the game. You can build a depot, which is your primary base of operations and through which you can build sniper nests, barricades, workshops to salvage buildings and rubbles for resources like Ammunition to kill zombies, Boards to build barricades and other structures, survivors who help build and scavenge etc. In this “tower defense” RTS, you are a survivor with the aim of freeing each island of the hordes of the undead. Shattered Colony: The Survivorsĭo you remember your good old GBA days? A browser based, Flash Player enabled game, developer Duerig’s ‘Shattered Colony: The Survivors’ provides a similar top view of in game islands that are infested with zombies. The game music and cartoon-ish appearance deserves special mention for it is the most important aspect that keeps the player fixated. Flicking your finger in the direction zombies are coming from is easy, but doing it without flinching in the face of overflowing odds is the real challenge in this tried and tested score oriented never-ending game format. You can play several of these top Zombie survival games online.Ī simple yet attention grabbing game for the handheld device here, where all you need to do is help a muscular hero beat the knickers off a horde of green cartoon-ish Zombies. With that said, let’s proceed to the list. Just as games like ‘The Last of Us’ or developer Telltale Games’ ‘The Walking Dead’ (set in the same universe shown on the comic and TV show of the same name) show us the more detailed, emotionally driven side of what could happen if civilization really fell to a Zombie Apocalypse, there are other much lesser known but equally interesting, heart pounding takes on a Zombie Apocalypse by dedicated developers, who decided to keep their brainchild FREE. But the Maquis had other plans as they discovered the Plantars were, in fact, talaxians. The four of them were found by Sasha and were taken in as guests. 1 and 2′ for reference)Īs it turns out, she and the Plantars were stranded on a very small and hidden planet the Maquis used as a base for operations. The entire time, Anne discovered that Voyager was missing in the Delta quadrant from claims by the Kazons and was declared “taken over” by them and their captain “dead” (see episode ‘Basics pt. After that, she was determined to go back and the Plantars agreed to help cause they’re family. ![]() There, she met the Plantars, simple talaxian farmers who adopted her the moment she told her story. She crash-landed on the planet Talax on the region of Wartwood, lost her only means of communications, limited to universal translations. When the wormhole dissipate, she realized that she was no longer on the Alpha quadrant, but on the Delta quadrant. She discovered it wasn’t just a strange ionic storm on space, it was a wormhole and she was sucked in. At first, she tried to break through the storm and went deeper, but when she tried to escape, she was pulled into the storm. Meanwhile, Anne, receiving a distress call from the ship, decided to turn back but a weird “ionic storm” formed around her path. Their leader, Gul Andrias, told her that in Cardassia, everyone’s accepted on their own terms and that she could lead whatever adventure she wanted, and it toyed with her mind and need to be accepted and separated from the Vulcan norm, so she joined with the Cardassians, unaware of their manipulation Marcy was at the mercy of the Cardassians who aided and cared for her, earning her full trust on the moment notice. But after her show of physical prowess, Grime offered her a place on the Maquis and she accepted as her deep-rooted dislike for Starfleet showed. 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The amount of cfDNA ranges from 1 to 100 ng/mL in the plasma, and the allele frequency of tumor DNA in cfDNA is very low, often lower than 1%. ![]() The technical challenge becomes even greater when cancer somatic mutations are interrogated from liquid biopsies such as plasma cell-free DNA (cfDNA) samples. Clinical tissue specimens available for genetic profiling are often minute, which regularly consist of several sections of formalin-fixed paraffin embedded (FFPE) tissues or needle biopsy samples. While the detection of low variant allele fractions (VAFs) requires the sequencing of a sufficient number of molecules, low quantity and quality of DNA extracted from clinical tissue samples often pose obstacles. ![]() Īs we recently reported, significant proportions of clinically actionable variants have allele fractions as low as less than 5%, often because of low tumor purity, heterogeneity, and secondary tumor driver mutations resulting from treatment. While the targeted sequencing method has been successfully employed for clinical genomic profiling, sufficient sequencing coverage was repeatedly suggested as a prerequisite for the successful implementation of the method in clinical cancer genome profiling. The advantages of targeted deep sequencing are particularly obvious in clinical settings where the selection of therapy is the primary reason for genomic profiling and only a small fraction of identified mutations are potentially responsive to a therapy (i.e., actionable mutations). Whereas whole genome sequencing (WGS) or whole exome sequencing (WES) provides additional information on genomic variants across broad regions of the human genome, targeted sequencing offers distinct advantages over these methods by reducing costs and simplifying data management/analysis. Furthermore, cataloging the most frequently mutated cancer genes across various cancer types has made targeted resequencing an attractive option to cost-effectively analyze genetic alterations in tumor specimens. Because the kits displayed significant variability in different quality metrics, our study offers a practical guideline for researchers to choose appropriate options for PCR-based targeted sequencing and useful benchmark data for evaluating new kits.Ĭancer genome profiling by massively parallel sequencing has rapidly advanced our understanding of the molecular characteristics underlying tumorigenesis. This study is the first systematic evaluation of commercial library construction kits for PCR-based targeted deep sequencing utilizing UMIs. The targeted deep sequencing method based on PCR target enrichment combined with UMI tagging sensitively detected mutations present at a frequency as low as 1% using 6.25 ng of human genomic DNA as the starting material. Based on these comparisons, we selected the Qiagen HASTP for further performance evaluations. We also analyzed the UMIs, including errors, which allowed us to adjust the depth of unique coverage and the length required for sufficient complexity. Regarding the coverage uniformity, the kits from Nugen and NEB performed the best followed by the kits from Qiagen. While the duplicate rates for all kits were dramatically decreased by identifying unique molecules with UMIs, the Qiagen HASTP achieved the highest library complexity based on the depth of unique coverage indicating superb library construction efficiency. We evaluated and compared the performances of the five kits using 50 ng of genomic DNA for the library construction in terms of the library complexity, coverage uniformity, and errors in the UMIs. In this study, we evaluated and compared the performances of five commercial library kits from four vendors: the Archer® Reveal ctDNA™ 28 Kit, NEBNext Direct® Cancer HotSpot Panel, Nugen Ovation® Custom Target Enrichment System, Qiagen Human Comprehensive Cancer Panel(HCCP), and Qiagen Human Actionable Solid Tumor Panel(HASTP). ![]() Currently, several commercial library construction kits based on PCR enrichment are available for UMIs, but there have been no systematic studies to compare their performances. Recently, this limitation was overcome by assigning a unique molecular identifier(UMI) to each template molecule. Despite the advantages of efficient enrichment, PCR-based methods preclude the identification of PCR duplicates and their subsequent removal. 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![]() The influences of I Love a Mystery and Dobie Gillis were especially apparent in these early episodes Mark Evanier, who would write Scooby-Doo teleplays and comic book scripts in the 1970s and 1980s, identified each of the four teenagers with their corresponding Dobie Gillis character: "Fred was based on Dobie, Velma on Zelda, Daphne on Thalia and Shaggy on Maynard." The similarities between Shaggy and Maynard are the most noticeable both characters share the same beatnik-style goatee, similar hairstyles, and demeanours. Seventeen episodes of Scooby-Doo were produced in 1969. The original voice cast featured Don Messick as Scooby-Doo, Casey Kasem as Shaggy, Frank Welker as Fred, Nicole Jaffe as Velma, and Stefanianna Christopherson as Daphne. Scooby-Doo, Where are You? made its CBS network debut on Saturday, Septemwith its first episode, "What a Night for a Knight". According to Ruby and Spears, Silverman was inspired by the ad-lib "doo-be-doo-be-doo" he heard at the end of Frank Sinatra's interpretation of Bert Kaempfert's song "Strangers in the Night" on the way out to one of their meetings, and decided to rename the dog "Scooby-Doo" and re-rechristened the show Scooby-Doo, Where are You? The revised show was re-presented to CBS executives, who approved it for production. They dropped the rock band element, and began to focus more attention on Shaggy and Too Much. Now without a centerpiece for the upcoming season's programming, Silverman turned to Ruby and Spears, who reworked the show to make it more comedic and less frightening. The executives felt that the presentation artwork was far too frightening for young viewers, and, thinking the show would be the same, decided to pass on it. ![]() ![]() Also, Silverman, not being very fond of the name Mysteries Five, had rechristened the show Who's S-S-Scared? Using storyboards, presentation boards, and a short completed animation sequence, Silverman presented Who's S-S-Scared? to the CBS executives as the centerpiece for the upcoming 1969–1970 season's Saturday morning cartoon block. After learning the characteristics of a prize-winning Great Dane from her, Takamoto proceeded to break most of the rules and designed Too Much with overly bowed legs, a double-chin, and a sloped back, among other abnormalities.īy the time the show was ready for presentation by Silverman, a few more things had changed: Geoff and Mike were merged into one character called "Ronnie" (later renamed "Fred", at Silverman's behest), Kelly was renamed to "Daphne", Linda was now called "Velma", and Shaggy (formerly "W.W.") was no longer her brother. Takamoto consulted a studio colleague who happened to be a breeder of Great Danes. Ruby and Spears had feared the Great Dane would be too similar to the comic strip character Marmaduke, but Barbera assured them it would not be a problem. After consulting with Barbera on the issue, Too Much was finally set as a Great Dane, primarily to avoid a direct correlation to The Archies (who had a sheepdog, Hot Dog, in their band). When the former was chosen, then the options became a large goofy Great Dane or a big shaggy sheepdog. At first, they chose between a large cowardly dog, and a small fiesty dog. Ruby and Spears then had to decide what to make their dog. When "The Mysteries Five" weren't performing at gigs, they were out solving spooky mysteries involving ghosts, zombies, and other supernatural creatures. Their original concept of the show bore the title Mysteries Five, and featured five teens (Geoff, Mike, Kelly, Linda, and Linda's brother "W.W.") and their dog, Too Much, who were all in a band called "The Mysteries Five" (even the dog he played the bongos). Hanna and Barbera passed this task along to two of their head storymen, Joe Ruby and Ken Spears, and artist/character designer Iwao Takamoto. Silverman envisioned the show as a cross between the popular I Love a Mystery radio serials of the 1940s and the popular early 1960s TV show The Many Loves of Dobie Gillis. Silverman was eager to expand upon this success, and contacted producers William Hanna and Joseph Barbera about possibly creating another show based around a teenage rock-group, but with an extra element: the kids would solve mysteries in-between their gigs. Also successful were the musical numbers The Archies performed during each program (one of which, "Sugar, Sugar", was the most successful Billboard number-one hit of 1969). The result was The Archie Show, based upon Bob Montana's teenage humor comic book Archie. In 1968, Fred Silverman, executive in charge of children's programming for the CBS network, was looking for a show that would revitalize his Saturday morning line-up and please the watchdog groups at the same time. |
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